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. 1978 Mar 1;169(3):721-4.
doi: 10.1042/bj1690721.

Proteinase inhibitors of bovine nasal cartilage

P J Roughley, G Murphy, A J Barrett

Proteinase inhibitors of bovine nasal cartilage

P J Roughley et al. Biochem J. .

Abstract

Extracts from bovine nasal cartilage with 1 M-guanidinium chloride were fractionated by ultrafiltration. Gel chromatography of the low-molecular-weight material resolved three distinct fractions with inhibitory activity against (a) collagenases (22000 mol.wt.), (b) thiol proteinases cathepsin B and papain (13000 mol.wt.), and (c) trypsin and other serine proteinases (7000 mol.wt.).

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