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. 1984;26(5):609-12.
doi: 10.1007/BF00543494.

Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: clinical and pathophysiological implications

J E Hodler, R L Galeazzi, B Frey, M Rudhardt, A J Seiler

Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: clinical and pathophysiological implications

J E Hodler et al. Eur J Clin Pharmacol. 1984.

Abstract

The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65 +/- 0.4 h, the total clearance amounting to 70.1 +/- 19.2 ml/min. Peritoneal clearance was calculated to be 6.9 +/- 1 ml/min. After peritoneal instillation, the bioavailability was 63.9 +/- 5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.

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References

    1. J Pharm Sci. 1979 Aug;68(8):1071-4 - PubMed
    1. Kidney Int. 1983 Jan;23(1):22-8 - PubMed
    1. Chemotherapy. 1977;23(3):129-41 - PubMed

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