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. 1978 Apr;37(4):612-9.
doi: 10.1038/bjc.1978.91.

Serial cytogenetic studies of human colonic tumour xenografts

B R Reeves, J A Houghton
Free PMC article

Serial cytogenetic studies of human colonic tumour xenografts

B R Reeves et al. Br J Cancer. 1978 Apr.
Free PMC article

Abstract

Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed.

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