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. 1984 Sep;45(3):713-7.
doi: 10.1128/iai.45.3.713-717.1984.

Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii

S Schramek, J Kazar, Z Sekeyova, M A Freudenberg, C Galanos

Induction of hyperreactivity to endotoxin in mice by Coxiella burnetii

S Schramek et al. Infect Immun. 1984 Sep.

Abstract

Intraperitoneal inoculation of mice with live or killed Coxiella burnetii phase I or phase II cells induced a marked hyperreactivity to the lethal effect of bacterial endotoxin and was accompanied by a marked hepatosplenomegaly. The degree and duration of hyperreactivity depended on the dose of C. burnetii administered and were higher with phase I than with phase II cells. Sensitization to the lethal effects of endotoxin and induction of splenomegaly by phase I C. burnetii cells also proceeded in the endotoxin-resistant C3H/HeJ strain of mice. Preincubation of C. burnetii cells with the corresponding immune serum significantly diminished the ability of phase I but not phase II cells to induce hyperreactivity to endotoxin.

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