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. 1984;2(1):55-8.
doi: 10.1007/BF00173787.

Activity of Carbetimer in a human tumor cloning system

D L Kisner, P Mehta, G E Paget, D D Von Hoff

Activity of Carbetimer in a human tumor cloning system

D L Kisner et al. Invest New Drugs. 1984.

Abstract

The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was less than or equal to 50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.

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