[Protein as an edited random copolymer]
- PMID: 6472260
[Protein as an edited random copolymer]
Abstract
It is widely believed that the unique primary structure of a given protein is quite necessary for its folding into a certain three-dimensional structure as well as for its functioning and is a result of a directed selection in the course of biological evolution. The present paper provides arguments in favour of an alternative point of view according to which typical three-dimensional structures of globular proteins are characteristic even for random sequences of amino acid residues. Therefore it may be possible that primary structures of proteins are mainly examples of random amino acid sequences slightly edited in the course of biological evolution to impart them some additional (functional) meaning.
Similar articles
-
Protein structure and neutral theory of evolution.J Biomol Struct Dyn. 1986 Aug;4(1):137-56. doi: 10.1080/07391102.1986.10507651. J Biomol Struct Dyn. 1986. PMID: 3271433
-
[A theory of heteropolymers with frozen random primary structure: properties of the globular state, coil-globule transitions and possible biophysical applications].Biofizika. 1986 Nov-Dec;31(6):1045-57. Biofizika. 1986. PMID: 3801519 Russian.
-
[Biopolymers and evolution].Mol Biol (Mosk). 1985 Jan-Feb;19(1):55-66. Mol Biol (Mosk). 1985. PMID: 3885005 Review. Russian.
-
Contact pair dynamics during folding of two small proteins: chicken villin head piece and the Alzheimer protein beta-amyloid.J Chem Phys. 2004 Jan 15;120(3):1602-12. doi: 10.1063/1.1633253. J Chem Phys. 2004. PMID: 15268287
-
[A turning point in the knowledge of the structure-function-activity relations of elastin].J Soc Biol. 2001;195(2):181-93. J Soc Biol. 2001. PMID: 11727705 Review. French.
Cited by
-
Do natural proteins differ from random sequences polypeptides? Natural vs. random proteins classification using an evolutionary neural network.PLoS One. 2012;7(5):e36634. doi: 10.1371/journal.pone.0036634. Epub 2012 May 16. PLoS One. 2012. PMID: 22615786 Free PMC article.
-
Chemical and computer probing of RNA structure.Prog Nucleic Acid Res Mol Biol. 1996;53:131-96. doi: 10.1016/s0079-6603(08)60144-0. Prog Nucleic Acid Res Mol Biol. 1996. PMID: 8650302 Free PMC article. Review.