A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate)
- PMID: 6473905
- DOI: 10.1007/BF01852390
A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate)
Abstract
The following three regimens of anesthesia in mice were compared: (1) Ketamine 100 mg--xylazine 5 mg/kg b.wt. i.m., (2) pentobarbitone 50 mg/kg b.wt. i.p., and (3) carfentanyl 0.003 mg--etomidate 15 mg/kg b.wt. i.m. For these dosage rates the respiratory variables, i.e., respiratory rate, paO2, paCO2, pHa, BEa, HCO-3a, and the circulatory parameters, i.e., heart rate, mean arterial pressure and hematocrit, were determined during the conscious state, during surgical anesthesia, and at waking time. With ketamine and xylazine, the respiration was moderately decreased whereas the cardiovascular system was strongly depressed. Pentobarbitone induced a high respiratory depression but a lesser degree of circulatory depression. Analgesia was inadequate. Although there was a moderate respiratory and circulatory depression during anesthesia with carfentanyl and etomidate the drug-induced excitation and muscle spasms do not recommend this anesthetic combination for mice. Of these three methods, the combination of ketamine and xylazine is considered the most reliable for anesthesia of mice.
Similar articles
-
Comparison of the depressive effects of four anesthetic regimens on ventilatory and cardiovascular variables in the guinea pig.Comp Med. 2004 Feb;54(1):77-85. Comp Med. 2004. PMID: 15027622
-
A Comparison of Ketamine or Etomidate Combined with Xylazine for Intraperitoneal Anesthesia in Four Mouse Strains.J Am Assoc Lab Anim Sci. 2020 Sep 1;59(5):519-530. doi: 10.30802/AALAS-JAALAS-19-000129. Epub 2020 Jul 28. J Am Assoc Lab Anim Sci. 2020. PMID: 32723425 Free PMC article.
-
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats.Lab Anim Sci. 1987 Dec;37(6):736-42. Lab Anim Sci. 1987. PMID: 3125387
-
Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats.J Am Assoc Lab Anim Sci. 2007 Mar;46(2):74-80. J Am Assoc Lab Anim Sci. 2007. PMID: 17343357
-
Injectable anesthetics and anesthetic adjuncts.Vet Clin North Am Equine Pract. 1987 Apr;3(1):15-36. doi: 10.1016/s0749-0739(17)30689-2. Vet Clin North Am Equine Pract. 1987. PMID: 3555725 Review.
Cited by
-
The mode of anesthesia influences outcome in mouse models of arterial thrombosis.Res Pract Thromb Haemost. 2019 Feb 15;3(2):197-206. doi: 10.1002/rth2.12184. eCollection 2019 Apr. Res Pract Thromb Haemost. 2019. PMID: 31011704 Free PMC article.
-
Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae).PLoS One. 2019 Apr 1;14(4):e0214574. doi: 10.1371/journal.pone.0214574. eCollection 2019. PLoS One. 2019. PMID: 30934013 Free PMC article.
-
Demonstration of an early and a late phase of ischemic preconditioning in mice.Am J Physiol. 1998 Oct;275(4):H1375-87. doi: 10.1152/ajpheart.1998.275.4.H1375. Am J Physiol. 1998. PMID: 9746488 Free PMC article.
-
A genetic and pathologic study of a DENV2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent mice.PLoS One. 2012;7(9):e44984. doi: 10.1371/journal.pone.0044984. Epub 2012 Sep 13. PLoS One. 2012. PMID: 23028722 Free PMC article.
-
A Comparative pO2 Probe and [18F]-Fluoro-Azomycinarabino-Furanoside ([18F]FAZA) PET Study Reveals Anesthesia-Induced Impairment of Oxygenation and Perfusion in Tumor and Muscle.PLoS One. 2015 Apr 22;10(4):e0124665. doi: 10.1371/journal.pone.0124665. eCollection 2015. PLoS One. 2015. PMID: 25902054 Free PMC article.