Antibiotic concentration in the serum of dogs and cats following a single oral dose of cephalexin

Abstract

Six dogs and six cats were given a single oral tableted dose containing approximately 15 mg/kg bodyweight of the semisynthetic cephalosporin antibiotic, cephalexin. Three dogs and four cats were similarly dosed using a liquid preparation of the same antibiotic. At intervals after dosing, blood samples were taken and the level of antibiotic in the serum was determined by bioassay. After fitting the results to a mathematical model the calculated peak serum level of antibiotic was found to be about 15 micrograms/ml and to occur between one and two hours after dosing. Results agree with the performance of the antibiotic in human medicine.