Serum and platelet lipoamide dehydrogenase in Friedreich's ataxia
- PMID: 647485
Item in Clipboard
Serum and platelet lipoamide dehydrogenase in Friedreich's ataxia
Can J Neurol Sci.
1978 Feb.
Abstract
Pyruvate dehydrogenase (PDH), alpha-keto glutarate dehydrogenase (alpha-KGDH) and lipoamide dehydrogenase (LAD) were measured in platelets of 11 patients with typical Friedreich's ataxia and 10 normal control subjects. Serum LAD was also evaluated in the same patients. No statistically significant changes were found in platelets for the group as a whole, although some patients had low values (more than one standard deviation below control mean). Serum LAD was significantly reduced in the patients with Friedreich's ataxia. This was not due to associated diabetes.
Similar articles
-
Friedreich's ataxia: I. Normal pyruvate dehydrogenase complex activity in platelets.Ann Neurol. 1978 Oct;4(4):366-8. doi: 10.1002/ana.410040412. Ann Neurol. 1978. PMID: 727741 No abstract available.
-
Evidence for a primary defect of lipoamide dehydrogenase in Friedreich's ataxia.Adv Neurol. 1978;21:163-80. Adv Neurol. 1978. PMID: 104555 Review.
-
Normal pyruvate dehydrogenase complex activity in patients with Friedreich's ataxia.Ann Neurol. 1980 Dec;8(6):636-9. doi: 10.1002/ana.410080618. Ann Neurol. 1980. PMID: 7212654 No abstract available.
-
Active pyruvate dehydrogenase in platelets from Friedreich's ataxia patients.Can J Neurol Sci. 1980 Nov;7(4):417-9. doi: 10.1017/s0317167100022988. Can J Neurol Sci. 1980. PMID: 7214256
-
Pyruvate dehydrogenase complex in Friedreich's ataxia.Adv Neurol. 1978;21:203-17. Adv Neurol. 1978. PMID: 367116 Review. No abstract available.
Cited by
-
Exclusion of the Friedreich ataxia gene from chromosome 19.Hum Genet. 1987 Jun;76(2):186-90. doi: 10.1007/BF00284919. Hum Genet. 1987. PMID: 3475247
-
Mitochondrial Alpha-Keto Acid Dehydrogenase Complexes: Recent Developments on Structure and Function in Health and Disease.Subcell Biochem. 2024;104:295-381. doi: 10.1007/978-3-031-58843-3_13. Subcell Biochem. 2024. PMID: 38963492 Review.
-
Friedreich's ataxia. I. Clinical, neurophysiological and in vivo biochemical studies.Ital J Neurol Sci. 1980 Oct;1(4):231-8. doi: 10.1007/BF02336703. Ital J Neurol Sci. 1980. PMID: 7338457
-
Nongradient blue native gel analysis of serum proteins and in-gel detection of serum esterase activities.J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Feb 15;879(5-6):386-94. doi: 10.1016/j.jchromb.2010.12.026. Epub 2010 Dec 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21237726 Free PMC article.
-
[Glutamate and GABA concentration in the brain and cerebrospinal fluid of rats treated with phosphatidylcholine].Arch Psychiatr Nervenkr (1970). 1982;232(1):33-8. doi: 10.1007/BF00343363. Arch Psychiatr Nervenkr (1970). 1982. PMID: 6128966 German.