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. 1984 Aug;59(8):762-5.
doi: 10.1136/adc.59.8.762.

Once a day theophylline; serum concentrations

V Nerminathan, S A McKenzie

Once a day theophylline; serum concentrations

V Nerminathan et al. Arch Dis Child. 1984 Aug.

Abstract

Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day. Peak concentrations occurred at a time when nocturnal wheezing is likely. Fluctuation in concentrations throughout the day was greater than with other currently available preparations, but the importance of this has yet to be determined.

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