doi: 10.1016/s0140-6736(77)91821-9.
Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia. Experience with 24 cases
- PMID: 64802
- DOI: 10.1016/s0140-6736(77)91821-9
Item in Clipboard
Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia. Experience with 24 cases
Lancet.
.
Abstract
Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia was attempted in 24 pregnancies. Adequate amounts of fetal blood (for studying globin-chain synthesis) were obtained in 22 cases. 4 cases of homozygous beta-thalassaemia and 2 of sickle-cell anaemia were diagnosed. The difference between the homozygous and non-homozygous states was well defined. Fetal bleeding from cord puncture and amnionitis resulted in the loss of three fetuses, and methods to avoid these complications are being devised. It is concluded that prenatal diagnosis of disorders of beta-globin synthesis is feasible.
Similar articles
-
Prenatal diagnosis of hemoglobinopathies. A review of 15 cases.N Engl J Med. 1976 Dec 23;295(26):1437-43. doi: 10.1056/NEJM197612232952601. N Engl J Med. 1976. PMID: 995141
-
Haematological and obstetric aspects of antenatal diagnosis of beta-thalassaemia: experience with 200 cases.J Med Genet. 1982 Apr;19(2):81-7. doi: 10.1136/jmg.19.2.81. J Med Genet. 1982. PMID: 7077630 Free PMC article.
-
Prenatal diagnosis of beta thalassemia: experience with 133 cases and the effect of fetal blood sampling on child development.Ann N Y Acad Sci. 1980;344:165-80. doi: 10.1111/j.1749-6632.1980.tb33659.x. Ann N Y Acad Sci. 1980. PMID: 6930866
-
Prenatal diagnosis of hemoglobin disorders.Prog Hematol. 1977;10:91-104. Prog Hematol. 1977. PMID: 337367 Review. No abstract available.
-
Prenatal diagnosis of thalassemias and hemoglobinopathies.Ann Clin Lab Sci. 1980 Sep-Oct;10(5):383-94. Ann Clin Lab Sci. 1980. PMID: 6252819 Review.
Cited by
-
The Progress and Future of US Newborn Screening.Int J Neonatal Screen. 2022 Jul 18;8(3):41. doi: 10.3390/ijns8030041. Int J Neonatal Screen. 2022. PMID: 35892471 Free PMC article. Review.
-
Prevention of homozygous beta-thalassemia by carrier screening and prenatal diagnosis in Sardinia.Am J Hum Genet. 1981 Jul;33(4):592-605. Am J Hum Genet. 1981. PMID: 7258188 Free PMC article.
-
Pitfalls in prenatal diagnosis of beta thalassaemia.J Med Genet. 1986 Oct;23(5):456-8. doi: 10.1136/jmg.23.5.456. J Med Genet. 1986. PMID: 3783623 Free PMC article.
-
Prenatal diagnosis of beta-thalassaemia by fetal red cell concentration with anti-AB serum.J Med Genet. 1979 Oct;16(5):366-8. doi: 10.1136/jmg.16.5.366. J Med Genet. 1979. PMID: 513082 Free PMC article.
-
Prenatal diagnosis of hemoglobinopathies: evaluation of techniques for analysing globin-chain synthesis in blood samples obtained by fetoscopy.Can Med Assoc J. 1982 Nov 1;127(9):843-9. Can Med Assoc J. 1982. PMID: 7139502 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
