Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat
- PMID: 6484313
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Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat
Res Commun Chem Pathol Pharmacol.
1984 Aug.
Abstract
The effect of butylated hydroxytoluene (BHT) on adriamycin (ADR)-induced skin ulcers was investigated using rats. The application of BHT reduced the size of the skin ulcers by the following amounts: topical application (20%); intradermal injection (50%); repeated applications of BHT (82%). Additional studies are required to determine if BHT will be a modifier of ADR extravasation in cancer patients.
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