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. 1984 Aug;45(2):289-92.

Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat

J P Daugherty, A Khurana, T A Simpson Jr
  • PMID: 6484313

Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat

J P Daugherty et al. Res Commun Chem Pathol Pharmacol. 1984 Aug.

Abstract

The effect of butylated hydroxytoluene (BHT) on adriamycin (ADR)-induced skin ulcers was investigated using rats. The application of BHT reduced the size of the skin ulcers by the following amounts: topical application (20%); intradermal injection (50%); repeated applications of BHT (82%). Additional studies are required to determine if BHT will be a modifier of ADR extravasation in cancer patients.

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