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. 1984 Sep 28;123(3):1209-14.
doi: 10.1016/s0006-291x(84)80261-2.

Inhibition of reconstituted vitamin D3 25-hydroxylase by a protein fraction from rat liver microsomes

I Holmberg

Inhibition of reconstituted vitamin D3 25-hydroxylase by a protein fraction from rat liver microsomes

I Holmberg. Biochem Biophys Res Commun. .

Abstract

A cytochrome P-450 fraction, containing vitamin D3 25-hydroxylase activity after reconstitution, was prepared from rat liver microsomes. The 25-hydroxylase activity increased considerably upon purification. A protein fraction isolated from the microsomes during the preparation markedly inhibited the reconstituted vitamin D3 25-hydroxylase activity. The inhibition was dependent on the amount of protein and completely reversed by heat treatment.

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