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. 1984 Sep;46(3):383-6.
doi: 10.1016/S0006-3495(84)84034-5.

Effect of colchicine on viscoelastic properties of neutrophils

S Chien, K L Sung

Effect of colchicine on viscoelastic properties of neutrophils

S Chien et al. Biophys J. 1984 Sep.

Abstract

The effect of colchicine (15-60 micrograms/ml) on the viscoelastic properties of human neutrophils was studied by the micropipette technique. The small deformation of the neutrophil in response to a step aspiration pressure was analyzed by using a three-element model in which an elastic element, K1, is in parallel with a Maxwell element composed of another elastic element, K2, in series with a viscous element, mu. Colchicine treatment of neutrophils caused decreases in K2 and mu without affecting K1. The results indicate that the integrity of the microtubules plays a significant role in providing the viscoelastic resistance (as represented by the Maxwell element in the model) of neutrophils to deforming stress.

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