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. 1984 Oct 8;311(1):186-8.
doi: 10.1016/0006-8993(84)91416-1.

Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression

G G Somjen

Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression

G G Somjen. Brain Res. .

Abstract

Changes in the pH of interstitial fluid were measured with H+-selective double-barreled micropipette electrodes in fascia dentata of urethane-anesthetized rats. Paroxysmal afterdischarges provoked by repetitive stimulation of an afferent fiber tract brought in their wake acidification by 0.07 to 0.2 pH units. Spreading depression caused acidification by 0.2-0.5 pH units. Acid shifts were often preceded by transient alkalinization. Acidification is attributed to the production of CO2 and of other acid metabolites.

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