Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Oct;77(10):830-2.
doi: 10.1177/014107688407701005.

Experimental colon neoplasia enhanced by extract of sperm (protamine)

R K Phillips, D S Quill, H A Dudley

Experimental colon neoplasia enhanced by extract of sperm (protamine)

R K Phillips et al. J R Soc Med. 1984 Oct.

Abstract

An experimental study of colorectal tumorigenesis in inbred rats given the potent carcinogen dimethylhydrazine has shown that protamine, given before any tumours had developed, significantly enhanced the development of large bowel tumours (100% incidence). Those animals having no adjuvant therapy or who received either heparin or 5-fluorouracil (alone or in combination) had an approximate 50% incidence of such tumours.

PubMed Disclaimer

References

    1. Gan. 1970 Apr;61(2):125-30 - PubMed
    1. Eur J Cancer. 1972 Jun;8(3):347-52 - PubMed
    1. Biol Gastroenterol (Paris). 1974;7(1):37-42 - PubMed
    1. Br J Cancer. 1975 Jul;32(1):60-77 - PubMed
    1. Acta Radiol Diagn (Stockh). 1978;19(5):799-816 - PubMed

Publication types

LinkOut - more resources