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. 1984 Aug 31;49(3):301-6.
doi: 10.1016/0304-3940(84)90306-9.

Dopaminergic activity is reduced in diabetic rats

C F Saller

Dopaminergic activity is reduced in diabetic rats

C F Saller. Neurosci Lett. .

Abstract

Dopamine synthesis rates in synaptosomes prepared from the striata of alloxan-diabetic rats were considerably lower than in control preparations. Striatal dopamine metabolite levels, after an initial increase, were also reduced at 3 and 6 weeks after alloxan administration. These findings suggest that dopaminergic functioning may be impaired in diabetic rats.

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