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. 1978 Mar;31(3):178-84.
doi: 10.7164/antibiotics.31.178.

Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative

G Cassinelli, A Grein, P Masi, A Suarato, L Bernardi, F Arcamone, A Di Marco, A M Casazza, G Pratesi, C Soranzo
Free article

Preparation and biological evaluation of 4-O-demethyldaunorubicin (carminomycin I) and of its 13-dihydro derivative

G Cassinelli et al. J Antibiot (Tokyo). 1978 Mar.
Free article

Abstract

A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by application of spectroscopic methods and chemical degradation. A new synthesis of 4-O-demethyl-daunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also reported.

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