Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Oct;43(5):673-8.
doi: 10.1136/ard.43.5.673.

Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor

I Teitsson, R H Withrington, M H Seifert, H Valdimarsson

Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor

I Teitsson et al. Ann Rheum Dis. 1984 Oct.

Abstract

Thirty-three patients with early arthritis, 28 of whom developed classical/definite rheumatoid arthritis (RA), were followed up for two to four years. Rheumatoid factor (RF) levels of the IgM, IgA, and IgG isotypes were measured in serum and synovial fluid by an ELISA technique developed in our laboratory. All seven patients who presented with raised IgA RF developed erosions of their hands and wrists. This was significantly different from the remaining 26. By contrast none of the five patients who presented with isolated elevation of IgM RF developed erosive disease. The patients with raised IgA RF needed significantly more treatment with 'specific' drugs than the remaining 26. It is suggested that the detection of IgA RF in early RA indicates poor prognosis, justifying a more aggressive treatment at an early stage.

PubMed Disclaimer

References

    1. Immunol Rev. 1982;67:87-114 - PubMed
    1. Ann Rheum Dis. 1959 Mar;18(1):24-8 - PubMed
    1. Immunology. 1963 Sep;6:421-33 - PubMed
    1. Ann Rheum Dis. 1964 May;23:193-204 - PubMed
    1. Bull World Health Organ. 1970;42(2):311-8 - PubMed

Publication types