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Comparative Study
. 1978 Mar;7(3):282-5.
doi: 10.1128/jcm.7.3.282-285.1978.

Immune adherence hemagglutination: alternative to complement-fixation serology

E T Lennette, D A Lennette
Comparative Study

Immune adherence hemagglutination: alternative to complement-fixation serology

E T Lennette et al. J Clin Microbiol. 1978 Mar.

Abstract

Immune adherence hemagglutination (IAHA) was compared to complement fixation (CF), using standard procedures, for serological testing of human sera with a number of commercially available antigens. The antigens included herpes simplex, measles, cytomegalo-, and influenza (type B) viruses, as well as Mycoplasma pneumoniae and Chlamydia psittaci (Chlamydia group). The IAHA test was found to be as specific as the CF test, but 4 to 20 times as sensitive with all antigens tested. Antigen titers were also higher with the IAHA method, and the time required to complete the test was only 4 h for the IAHA method, compared with 20 h for the CF method. The increased sensitivity of the IAHA test should permit its use for determination of immunity, as well as for serodiagnosis of recent infections.

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References

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