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. 1984 Sep;11(3):179-85.
doi: 10.1111/j.1600-0536.1984.tb00967.x.

Histological assessment of skin damage by irritants: its possible use in the evaluation of a 'barrier cream'

G Mahmoud, J M Lachapelle, D van Neste

Histological assessment of skin damage by irritants: its possible use in the evaluation of a 'barrier cream'

G Mahmoud et al. Contact Dermatitis. 1984 Sep.

Abstract

The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone-containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone-containing barrier cream.

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