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Case Reports
. 1984;68(1):70-2.
doi: 10.1007/BF00293876.

A unique electrophoretic slow-moving glucose 6-phosphate dehydrogenase variant (G6PD Asahikawa) with a markedly acidic pH optimum

T Takizawa, H Fujii, S Takegawa, K Takahashi, A Hirono, T Morisaki, H Kanno, R Oka, H Yoshioka, S Miwa
Case Reports

A unique electrophoretic slow-moving glucose 6-phosphate dehydrogenase variant (G6PD Asahikawa) with a markedly acidic pH optimum

T Takizawa et al. Hum Genet. 1984.

Abstract

A new glucose 6-phosphate dehydrogenase (G6PD) variant associated with chronic nonspherocytic hemolytic anemia was discovered in Japan. The patient showed hemolytic crises after upper respiratory infections. The enzyme activity was about 3.8% of the normal. The partially purified enzyme revealed slow anodal electrophoretic mobility, high Km NADP, marked thermal-instability, and increased affinity for a substrate analogue (deamino-NADP). A particular characteristic of this enzyme was a biphasic pH curve with a greatly increased activity at low pH values. From these results, this variant was clearly different from hitherto observed G6PD variants, and was designated G6PD Asahikawa.

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References

    1. Klin Wochenschr. 1970 Jan 15;48(2):74-8 - PubMed
    1. Blood. 1968 Feb;31(2):131-50 - PubMed
    1. Science. 1973 Feb 9;179(4073):532-7 - PubMed
    1. J Lab Clin Med. 1969 Dec;74(6):895-901 - PubMed
    1. Ann Hum Genet. 1973 Oct;37(2):151-5 - PubMed

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