Studies on chiasma frequency and distribution in two fertile men carrying reciprocal translocations; one with a t(9;10) karyotype and one with a t(Y;10) karyotype
- PMID: 6500577
- DOI: 10.1007/BF00418394
Studies on chiasma frequency and distribution in two fertile men carrying reciprocal translocations; one with a t(9;10) karyotype and one with a t(Y;10) karyotype
Abstract
The frequency and distribution of chiasmata was investigated in two fertile carriers of reciprocal translocations, one with a 46,XY,t(9;10)(p22;q24) karyotype and one with a 46,X,-Y,+der(Y),t(Y;10)(q12;q24) karyotype. In both cases the chromosomes involved in the translocation showed an increase in chiasma frequency in comparison to karyotypically normal controls and in both cases this increase was localised, affecting only one interstitial segment of each translocation quadrivalent. In the t(9;10) case chiasmata appeared in substantial numbers in a novel location, the proximal two thirds of 9p, while in the t(Y;10) case chiasmata appeared in a conventional location, the medial region of 10q, but at an increased frequency. Furthermore there was evidence for inter-chromosomal effects in the t(9;10) case.
Similar articles
-
Chiasma derived genetic lengths and recombination fractions: a 46, XY, t(9; 10) (p22; q24) reciprocal translocation.Ann Hum Genet. 1985 May;49(2):135-46. doi: 10.1111/j.1469-1809.1985.tb01685.x. Ann Hum Genet. 1985. PMID: 4073829
-
Meiotic association between the XY chromosomes and the autosomal quadrivalent of a reciprocal translocation in two infertile men, 46,XY,t(19;22) and 46,XY,t(17;21).Cytogenet Cell Genet. 1986;43(3-4):154-60. doi: 10.1159/000132314. Cytogenet Cell Genet. 1986. PMID: 3802918
-
Translocation (Y;19)(q12;q13) and azoospermia.Ann Genet. 1991;34(1):27-9. Ann Genet. 1991. PMID: 1952788
-
Two different XY-quadrivalent associations and impairment of fertility in men.Cytogenet Cell Genet. 1987;45(3-4):222-30. doi: 10.1159/000132458. Cytogenet Cell Genet. 1987. PMID: 3319437 Review.
-
Phenotype/karyotype correlations of Y chromosome aneuploidy with emphasis on structural aberrations in postnatally diagnosed cases.Am J Med Genet. 1994 Nov 1;53(2):108-40. doi: 10.1002/ajmg.1320530204. Am J Med Genet. 1994. PMID: 7856637 Review.
Cited by
-
Meiotic and sperm chromosome analysis in a male carrier of an inverted insertion (3;10)(q13.2;p14p13).J Med Genet. 1992 Jul;29(7):460-4. J Med Genet. 1992. PMID: 1640424 Free PMC article.
-
Genetic analysis of meiotic recombination in humans by use of sperm typing: reduced recombination within a heterozygous paracentric inversion of chromosome 9q32-q34.3.Am J Hum Genet. 1998 Jun;62(6):1484-92. doi: 10.1086/301863. Am J Hum Genet. 1998. PMID: 9585591 Free PMC article.
-
A t(Y;15) translocation with a deletion of the proximal Yq in a boy with mixed gonadal dysgenesis.Hum Genet. 1991 Mar;86(5):442-4. doi: 10.1007/BF00194630. Hum Genet. 1991. PMID: 2016085
-
Meiotic analysis by FISH of a human male 46,XY,t(15;20)(q11.2;q11.2) translocation heterozygote: quadrivalent configuration, orientation and first meiotic segregation.Chromosoma. 1993 Jan;102(2):102-11. doi: 10.1007/BF00356027. Chromosoma. 1993. PMID: 8432191
-
Electron microscopic investigations of synaptonemal complexes in an infertile human male carrier of a pericentric inversion inv(1)(p32q42). Regular loop formation but defective synapsis including a possible interchromosomal effect.Hum Genet. 1987 May;76(1):81-9. doi: 10.1007/BF00283055. Hum Genet. 1987. PMID: 3570302