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. 1984 Dec 10;259(23):14343-6.

Gamma-carboxyglutamate in a neuroactive toxin

J M McIntosh, B M Olivera, L J Cruz, W R Gray
  • PMID: 6501296
Free article

Gamma-carboxyglutamate in a neuroactive toxin

J M McIntosh et al. J Biol Chem. .
Free article

Abstract

The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.

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