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. 1984 Oct;47(10):1109-16.
doi: 10.1136/jnnp.47.10.1109.

Action of tizanidine on responses of forearm flexors and extensors to torque disturbances

R Mackel, E E Brink, Y Nakajima

Action of tizanidine on responses of forearm flexors and extensors to torque disturbances

R Mackel et al. J Neurol Neurosurg Psychiatry. 1984 Oct.

Abstract

The effects of tizanidine on the electromyographic responses of forearm flexors and extensors to torque disturbances were studied in normal subjects. Tizanidine had a strong depressive action on all the reflex responses, and on muscle background activity. It is concluded that the action on reflexes is not specific, but secondary to decreased spinal cord excitability.

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