Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Apr 20;40(1):67-76.
doi: 10.1007/BF01909739.

Quercetin inhibits hexose transport in a human diploid fibroblast

D W Salter, S Custead-Jones, J S Cook

Quercetin inhibits hexose transport in a human diploid fibroblast

D W Salter et al. J Membr Biol. .

Abstract

The flavonol quercetin, a phloretin analog, inhibits transport of 2-deoxyglucose and 3-O-methylglucose in a cultured human diploid fibroblast. This inhibition is related to transport itself and not to the reported effects of flavonoids on membrane-bound ATPases. From concentration-inhibition curves at several pH's we conclude that uncharged (acid) quercetin (pK = 7.65) is the inhibitory form of the molecule (K1 = 10micron). Quercetin, unlike phloretin, is rapidly degraded in 0.1 N NaOH; the degradation products are weakly inhibitory to hexose transport.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1974 Dec 16;344(3-4):263-305 - PubMed
    1. Biochemistry. 1976 Nov 16;15(23):4951-6 - PubMed
    1. Biochem Pharmacol. 1969 Jun;18(6):1495-500 - PubMed
    1. J Biol Chem. 1959 Nov;234:3022-6 - PubMed
    1. Mol Pharmacol. 1969 Nov;5(6):584-92 - PubMed

Publication types