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Case Reports
. 1984 Oct;6(5):491-7.
doi: 10.1097/00000372-198410000-00013.

Pathogenesis of ulcerations in deficiency of prolidase. The role of angiopathy and of deposits of amyloid

Case Reports

Pathogenesis of ulcerations in deficiency of prolidase. The role of angiopathy and of deposits of amyloid

G E Pierard et al. Am J Dermatopathol. 1984 Oct.

Abstract

The structure of the skin and the pattern of alteration in chronic ulcerations associated with deficiency of prolidase have been studied superficially in the past. We examined histologically several biopsies taken from apparently normal skin and from ulcerations afflicting a young woman with such a syndrome. Deposits of amyloid were found within the walls of medium-sized vessels and occasionally occluding their lumens. Impaired cutaneous microcirculation resulting from statis, moderate vasculitis, and abnormal structure of the dermis may be responsible for the regional preponderance of deposits of amyloid and ulcerations in the legs.

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