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. 1984 Nov 15;224(1):201-6.
doi: 10.1042/bj2240201.

Cycloheximide blocks changes in rat liver carnitine palmitoyltransferase 1 activity in starvation

E D Saggerson, M I Bird, C A Carpenter, K A Winter, J J Wright

Cycloheximide blocks changes in rat liver carnitine palmitoyltransferase 1 activity in starvation

E D Saggerson et al. Biochem J. .

Abstract

Starvation (24h) increased the maximum activity of carnitine palmitoyltransferase 1 in rat liver and increased the concentration of malonyl-CoA required to cause 50% inhibition of the enzyme (I50). Re-feeding (24h) with a standard cube diet or a high-carbohydrate diet reversed both of these changes, whereas re-feeding with a high-fat diet did not. Administration of cycloheximide (200 micrograms/100 g body wt.) blocked the increases in carnitine palmitoyltransferase 1 activity and I50 on starvation. It is suggested that increase in carnitine palmitoyltransferase 1 activity in starvation may involve synthesis of new enzyme.

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