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. 1984 Nov 30;125(1):30-4.
doi: 10.1016/s0006-291x(84)80329-0.

Enhancement of the in vitro antibody response by thyrotropin

J E Blalock, H M Johnson, E M Smith, B A Torres

Enhancement of the in vitro antibody response by thyrotropin

J E Blalock et al. Biochem Biophys Res Commun. .

Abstract

The pituitary hormone thyrotropin (TSH) has been shown to enhance in a dose dependent manner the in vitro antibody response. Highly purified preparations of bovine and human TSH enhanced up to 375% the number of cells producing antibody to sheep erythrocytes. TSH had to be present prior to 24-48h of the initiation of culture for enhancement of the antibody response. An analogy is discussed between TSH and B lymphocyte growth and differentiation factors.

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