doi: 10.1159/000124040.
Differential responses to osmotic stress of vasopressin-neurophysin mRNA in hypothalamic nuclei
- PMID: 6514139
- DOI: 10.1159/000124040
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Differential responses to osmotic stress of vasopressin-neurophysin mRNA in hypothalamic nuclei
Neuroendocrinology.
1984 Dec.
Abstract
mRNA encoding the vasopressin-neurophysin precursor was quantitated in individual hypothalamic nuclei of rats by a liquid hybridization assay. Drinking of 2% saline for 14 days, a treatment that increased the plasma vasopressin concentration 9-fold, resulted in a 5- and 2-fold increase in mRNA levels in the supraoptic and paraventricular nucleus, respectively. This osmotic stimulus had no effect on vasopressin-neurophysin mRNA content of the suprachiasmatic nucleus. This dissociation in regulation of vasopressin-neurophysin mRNA in hypothalamic nuclei indicates the existence of two separate vasopressin systems that are independently activated.
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