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. 1984 Oct;26(4):597-8.
doi: 10.1128/AAC.26.4.597.

In vitro activity of ciprofloxacin against aerobic gram-negative bacteria

J E Rudin, C W Norden, E M Shinners

In vitro activity of ciprofloxacin against aerobic gram-negative bacteria

J E Rudin et al. Antimicrob Agents Chemother. 1984 Oct.

Abstract

For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrowth by 24 h, with development of partial resistance to ciprofloxacin.

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References

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