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. 1984 Dec 28;125(3):1061-6.
doi: 10.1016/0006-291x(84)91391-3.

2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase in human plasma

H Sawai, K Ishibashi, M Itoh, S Watanabe

2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase in human plasma

H Sawai et al. Biochem Biophys Res Commun. .

Abstract

2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase activity were detected in the human plasma and serum by sensitive radioimmuno assays. The phosphodiesterase in the serum degraded 20 nM of added 2',5'-oligoadenylate in less than 1 hr. Addition of EDTA in the blood sample inhibited the phosphodiesterase activity completely and allowed the measurement of low levels of 2',5'-oligoadenylate. The concentration in the plasma from healty people was in the range of 0.03 to 0.3 nM.

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