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. 1984 Oct;11(10):539-44.
doi: 10.1002/bms.1200111009.

A stable isotope method for the quantification of N-acetyl-5-aminosalicylic acid in plasma and urine

C Fischer, C O Meese, U Klotz

A stable isotope method for the quantification of N-acetyl-5-aminosalicylic acid in plasma and urine

C Fischer et al. Biomed Mass Spectrom. 1984 Oct.

Abstract

The synthesis of a number of N-acyl-5-aminosalicylic acids and their derivatives is described. These compounds allow the sensitive and specific mass spectrometric determination of unlabelled or deuterium-labelled N-acetyl-5-aminosalicylic acid in biological samples. An in vivo study shows that the labelled compound, administered to rats, is excreted isotopically unchanged to at least 97%, and that no significant deacetylation/acetylation mechanism exists for this metabolite N-acetyl-5-aminosalicylic acid of salicylazosulphapyridine.

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