Effective dose equivalent from radiopharmaceuticals

Abstract

The concept of "effective dose equivalent", which was introduced by the International Commission on Radiological Protection (ICRP) for occupationally exposed workers, has also created the possibility of expressing by means of a single figure, the radiation risk to patients undergoing different medical radiodiagnostic procedures. In this study, we present the effective dose equivalent for various nuclear-medicine investigations. The figures given are primarily based on a review of data contained in the literature on the mean absorbed dose to various organs. In many cases, however, our own calculations, using biokinetic data derived from the literature, have been used. It was found that for the different radiopharmaceuticals, the effective dose equivalent per activity unit administered extends over an interval of five orders of magnitude, from 0.00015 to 20 mSv/MBq. For the technetium-labelled compounds, the absorbed dose for 90% of the substances lies within the narrower interval between 0.0060 and 0.025 mSv/MBq. With the aid of the figures presented, each nuclear medicine department will be able to estimate the effective dose equivalent and, hence, the risk to patients undergoing different investigations.