Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Mar;302(1):51-4.
doi: 10.1007/BF00586596.

Sensitization by caerulein of guinea-pig ileum to contractions by acetylcholine, histamine, 5-hydroxytryptamine and nicotine

J Fontaine, J P Famaey, J Reuse

Sensitization by caerulein of guinea-pig ileum to contractions by acetylcholine, histamine, 5-hydroxytryptamine and nicotine

J Fontaine et al. Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar.

Abstract

Low concentrations (0.63 and 1.25 ng/ml) of caerulein increase the submaximal contractions of the guinea-pig isolated ileum induced by several agonists and electrical stimulation. These effects of the polypeptide are due partly to neuronal pathways (i.e., a ganglionic stimulation) and partly to a non specific muscular sensitization. At higher concentrations of caerulein the effects of all the agonists were decreased. This seems related to the contractile effect of the peptide itself on the longitudinal muscle which interfers non specifically with the development of contractions induced by any other agonist.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Agents Actions. 1970 Aug;1(4):176-82 - PubMed
    1. Gut. 1970 Jan;11(1):79-87 - PubMed
    1. Br J Pharmacol. 1970 Jan;38(1):221-8 - PubMed
    1. J Physiol. 1955 Feb 28;127(2):40-1P - PubMed
    1. Acta Physiol Scand. 1967 Jun;70(2):250-4 - PubMed