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Comparative Study
. 1984 Dec;11(6):772-5.

Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

P M Brooks, J O Miners, K Smith, M D Smith, I Fearnley, D J Birkett
  • PMID: 6520830
Comparative Study

Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

P M Brooks et al. J Rheumatol. 1984 Dec.

Abstract

Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.

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