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. 1984:(15):93-6.

A rapid internucleotide bond formation for the phosphotriester approach by use of new condensing reagents

J Matsuzaki, H Hotoda, M Sekine, T Hata
  • PMID: 6522301

A rapid internucleotide bond formation for the phosphotriester approach by use of new condensing reagents

J Matsuzaki et al. Nucleic Acids Symp Ser. 1984.

Abstract

Bis(2,4,6-trihalophenyl) phosphorochloridates (TCP and TBP) were found to be effective as condensing reagents for the rapid internucleotidic phoshotriester bond formation. The benzoyl group as the N3-imide protecting group of thymidine was also useful for prevention of the side reaction caused by the active condensing reagents.

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