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. 1984 Dec;26(6):935-6.
doi: 10.1128/AAC.26.6.935.

Ciprofloxacin penetration into extravascular spaces in a rabbit model

K L Nichol, L R Peterson, C E Fasching, D N Gerding

Ciprofloxacin penetration into extravascular spaces in a rabbit model

K L Nichol et al. Antimicrob Agents Chemother. 1984 Dec.

Abstract

Ciprofloxacin penetration into extravascular spaces was studied in a rabbit Visking chamber model. The drug was administered (7 mg/kg) intramuscularly every 4 h for eight doses. Peak and trough drug levels by dose 8 were 1.3 and 0.35 micrograms/ml in serum and 0.61 and 0.50 micrograms/ml in extravascular sites. The ratio of extravascular site to serum free drug area under the drug curve by dose 8 was 91.1%. This potent, new antimicrobial agent appears to distribute freely to extravascular spaces in this animal model.

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References

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