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. 1984 Dec 15;224(3):1023-6.
doi: 10.1042/bj2241023.

Membrane solubility of chlorpromazine. Hygroscopic desorption and centrifugation methods yield comparable results

M Luxnat, H J Müller, H J Galla

Membrane solubility of chlorpromazine. Hygroscopic desorption and centrifugation methods yield comparable results

M Luxnat et al. Biochem J. .

Abstract

Binding of the positively charged drug chlorpromazine to artificial and erythrocyte bilayer membranes was investigated by the filtration method called hygroscopic desorption [Conrad & Singer (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 5202-5206] and by the conventional centrifugation method. Only minor differences in the partition coefficients were observed using the two methods. Our finding is not consistent with the observation of Conrad & Singer that amphipaths are completely excluded from biological membranes. However, the partition coefficient is dependent on membrane composition, which means dependent on the physical properties of a membrane.

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