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. 1984 Dec 15;224(3):741-6.
doi: 10.1042/bj2240741.

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

G M Burgess, R F Irvine, M J Berridge, J S McKinney, J W Putney Jr

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

G M Burgess et al. Biochem J. .

Abstract

In permeabilized hepatocytes, inositol 1,4,5-trisphosphate, inositol 2,4,5-trisphosphate and inositol 4,5-bisphosphate induced rapid release of Ca2+ from an ATP-dependent, non-mitochondrial vesicular pool, probably endoplasmic reticulum. The order of potency was inositol 1,4,5-trisphosphate greater than inositol 2,4,5-trisphosphate greater than inositol 4,5-bisphosphate. The Ca2+-releasing action of inositol 1,4,5-trisphosphate is not inhibited by high [Ca2+], nor is it dependent on [ATP] in the range of 50 microM-1.5 mM. These results suggest a role for inositol 1,4,5-trisphosphate as a second messenger in hormone-induced Ca2+ mobilisation, and that a specific receptor is involved in the Ca2+-release mechanism.

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References

    1. Biochim Biophys Acta. 1975 Mar 25;415(1):81-47 - PubMed
    1. J Biol Chem. 1961 Jul;236:1902-6 - PubMed
    1. Biochem J. 1979 Feb 15;178(2):497-500 - PubMed
    1. FEBS Lett. 1980 Jun 30;115(2):243-6 - PubMed
    1. Biochem Soc Trans. 1981 Oct;9(5):377-9 - PubMed

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