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. 1984;6(4):291-304.
doi: 10.3109/08923978409028605.

In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA)

R Ruffmann, R D Welker, T Saito, M A Chirigos, L Varesio

In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA)

R Ruffmann et al. J Immunopharmacol. 1984.

Abstract

Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.

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