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. 1984 Dec;18(6):873-7.
doi: 10.1111/j.1365-2125.1984.tb02558.x.

Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients

S Jawad, A Richens, J Oxley

Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients

S Jawad et al. Br J Clin Pharmacol. 1984 Dec.

Abstract

The pharmacokinetics of clobazam were studied in six healthy volunteers and six age and sex matched enzyme-induced epileptic patients. In the epileptic patients the area under the plasma concentration-time curve for clobazam was significantly smaller and the area under the plasma concentration-time curve for N-desmethylclobazam was significantly greater than in the healthy volunteers. Plasma N-desmethylclobazam concentrations were found to be much higher than those of clobazam in the epileptic patients, raising the possibility that the antiepileptic properties of clobazam are to be attributed more to its metabolite than the parent drug.

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References

    1. Biochem Pharmacol. 1970 May;19(5):1771-6 - PubMed
    1. Drug Metab Dispos. 1973 Jan-Feb;1(1):411-7 - PubMed
    1. Br J Clin Pharmacol. 1976 Apr;3(2):321-5 - PubMed
    1. Clin Pharmacol Ther. 1978 Sep;24(3):316-23 - PubMed
    1. Br J Clin Pharmacol. 1979;7 Suppl 1:41S-50S - PubMed