Detection of oncornavirus-like particles in normal and tumorigenic rat liver cell cultures
- PMID: 65305
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Detection of oncornavirus-like particles in normal and tumorigenic rat liver cell cultures
Gan.
1976 Oct.
Abstract
Six epithelial cell cultures established from adult Wistar rat liver were examined by electron microscopy for oncornavirus-like particles. Two heteroploid and tumorigenic cultures demonstrated many cells with virus-like particles of type-A and type-C morphology. The remaining four, composed of diploid nontumorigenic cells, demonstrated similar virus-like particles but in few cells and only after bromodeoxyuridine treatment. The virus-like particles in the tumorigenic cultures were identified as a rat type-C virus by serological assays.
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