Metabolism of nitrosamines by cytochrome P-450 isozymes
- PMID: 6533032
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Metabolism of nitrosamines by cytochrome P-450 isozymes
IARC Sci Publ.
1984.
Abstract
Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.
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