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. 1984:(57):423-8.

Metabolism of nitrosamines by cytochrome P-450 isozymes

C S Yang, Y Y Tu, J Hong, C Patten
  • PMID: 6533032

Metabolism of nitrosamines by cytochrome P-450 isozymes

C S Yang et al. IARC Sci Publ. 1984.

Abstract

Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.

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