The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB)
- PMID: 6534006
- DOI: 10.1016/0042-6989(84)90016-6
The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB)
Abstract
We have obtained electroretinograms (ERGs) from rabbits and macaque monkeys after vitreal administration of 2-amino-4-phosphonobutyrate (APB), which selectively blocks light-responsiveness in retinal on-bipolar cells. Microelectrode recordings from central visual structures provided an independent measure of the drug effects. In rabbits, APB blocked the b-wave, a sustained corneal-positive potential, and a transient corneal-negative off-response. In monkeys, APB abolished the b-wave but had little or no effect on the d-wave. The d-wave could be eliminated, however, by the use of broadband blue stimuli. The results are discussed in light of recent hypotheses about the cellular origins of the ERG.
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