Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;24(12):1841-6.
doi: 10.1016/0042-6989(84)90016-6.

The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB)

The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB)

A G Knapp et al. Vision Res. 1984.

Abstract

We have obtained electroretinograms (ERGs) from rabbits and macaque monkeys after vitreal administration of 2-amino-4-phosphonobutyrate (APB), which selectively blocks light-responsiveness in retinal on-bipolar cells. Microelectrode recordings from central visual structures provided an independent measure of the drug effects. In rabbits, APB blocked the b-wave, a sustained corneal-positive potential, and a transient corneal-negative off-response. In monkeys, APB abolished the b-wave but had little or no effect on the d-wave. The d-wave could be eliminated, however, by the use of broadband blue stimuli. The results are discussed in light of recent hypotheses about the cellular origins of the ERG.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources