Effect of carbanilate local anesthetics on granulation tissue formation

Abstract

The effect of local anesthetics pentacaine ((+/-)-trans N-/2-(3-pentyloxy-phenylcarbamoyloxy)-cyclohexyl/- pyrrolidinium chloride), heptacaine (N-/2-(2-heptyloxy-phenyl-carbamoyloxy)-ethyl/-piperidini um chloride) and trimecaine (2, 4, 6-trimethylphenylcarbamoyl)-methyldiethylammonium chloride) on granulation tissue formation in open skin wounds was examined in rats. The anesthetics applied on the wounds 3 times a day for 5 days caused increase in granulation tissue weight, in DNA and hydroxyproline contents. Pentacaine had the most pronounced effects (190% dry weight, 253% DNA and 148% hydroxyproline content when compared to saline-treated controls). The smallest changes were observed after heptacaine treatment.