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. 1984;12(1):36-8.
doi: 10.1007/BF00255906.

Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function

Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function

J J Offerman et al. Cancer Chemother Pharmacol. 1984.

Abstract

Ten previously untreated patients with metastatic non-seminomatous testicular carcinoma received cis-diamminedichloroplatinum (CDDP). Renal function studies were performed before and following the first CDDP infusion. A decrease in effective renal plasma flow (ERPF) and an increase in filtration fraction (FF) was found in all patients. These findings suggest primary changes in renal hemodynamics during CDDP infusion.

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