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. 1984 Jul;34(7):966-8.
doi: 10.1212/wnl.34.7.966.

Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis

P R Martin, S Higa, R S Burns, L Tamarkin, M H Ebert, S P Markey

Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis

P R Martin et al. Neurology. 1984 Jul.

Abstract

Mean (+/- SEM) urinary excretion rate of the major melatonin metabolite 6-hydroxymelatonin (micrograms/day) was lower in 7 (2.8 +/- 1.0) of 8 men with Korsakoff's psychosis (KP) than in 15 healthy men (11.4 +/- 1.4). Treatment with the alpha 2-noradrenergic agonist clonidine decreased daily 6-hydroxymelatonin excretion (p less than 0.02). Reduced daily excretion of 6-hydroxymelatonin in KP reflects decreased melatonin synthesis in the pineal gland, perhaps as a residual effect of lesions due to past thiamine deficiency (Wernicke's encephalopathy).

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